Buy Gonadorelin (GnRH) (10mg) Online. Gonadorelin (GnRH) is a decapeptide gonadotropin-releasing hormone agonist.^[1] It appears to work by stimulating the synthesis and release of luteinizing hormone and follicle-stimulating hormone. It is being researched within the context of infertility and reproductive systems, and hypogonadism. It is also studied for its potential as a diagnostic tool to assess pituitary function.^[2]

Specifications

Molecular Formula: C₅₅H₇₅N₁₇O₁₃

Sequence: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly

Molecular Weight: 1182.311 g/mol

Other Known Titles: Growth Hormone Releasing Factor, Somatocrinin, Somatoliberin

Gonadorelin Research

Gonadorelin and GnRH Receptors
Similar to GnRH, Gonadorelin is posited to exert its actions through the GnRH receptors. However, these receptors appear to be highly sensitive to downregulation. While intermittent exposure to GnRH and Gonadorelin activates these receptors to produce physiological actions like LH and FSH release, continuous activation via Gonadorelin might downregulate and inactivate the receptors, turning them unresponsive to native GnRH.^[3] Therefore, the method of experimentation may be crucial, in whether Gonadorelin will upregulate or downregulate the release of LH and FSH, which are considered crucial in the functioning of the hypothalamic-pituitary-gonadal (HPG) axis. The suppressive actions of Gonadorelin on LH/FSH production may have research potential in experimentation with cancer cells and experimental models of dementia. On the other hand, its stimulating action during intermittent exposure is investigated for kick-starting the HPG axis and in experimental models of cryptorchidism and spermatogenesis problems.