Buy CJC-1295 DAC (5mg) Online

Buy CJC-1295 DAC (5mg) Online. CJC-1295 DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) that has the potential to enhance plasma levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).^[1] Drug affinity complex (DAC) is an additive component that is considered to prolong the half-life of CJC-1295. Researchers have created several synthetic modifications of growth hormone-releasing hormone (GHRH), which appear to retain certain selective traits of the hormone while eliminating others. CJC-1295 is one such synthetic analog, comprising the first 29 amino acids of GHRH. This is believed to lend secretagogue characteristics with greater solubility, which may be easier to synthesize in larger volumes.

CJC-1295 DAC shares similarities with other GHRH analogs like Sermorelin, as both are derivatives of the first 29 amino acids of GHRH. CJC-1295 is structurally identical to Modified GRF (1-29). In particular, CJC-1295 DAC and Mod GRF (1-29) exhibit four alterations within their 29 amino acid sequence, specifically at the 2nd, 8th, 15th, and 27th positions. These modifications are hypothesized to enhance the peptides’ resistance to enzymatic breakdown, particularly by dipeptidyl peptidase-4 (DPP-4). For instance, the replacement of L-alanine with D-alanine at the 2nd position may contribute to increased resistance to molecular degradation. Substituting asparagine with glutamine at the 8th position may conceivably reduce the likelihood of asparagine rearrangement and amide hydrolysis. The substitution of glycine with alanine at the 15th position is suggested to enhance bioactivity. Finally, the alteration from methionine to leucine at the 27th position is thought to aid in mitigating the risk of methionine oxidation. The primary differential between the two peptides, CJC-1295 DAC and Mod GRF (1-29), is the addition of DAC to the CJC-1295 molecule. DAC is attached to CJC-1295 through a lysine linker to extend the peptide’s pharmacokinetics. DAC appears to facilitate the association of peptides with blood proteins such as albumin. This appears to enhance their half-life, as compared to similar peptides such as GRF (1-29).^[2] This occurrence may be attributed to the purported ability of DAC to interact with plasma proteins. Specifically, it seems that the DAC element involves the association of a lysine derivative, N-epsilon-3-maleimidopropionamide, with the C-terminus of CJC-1295 DAC. The incorporation of this altered amino acid sequence into the DAC configuration may plausibly improve the pharmacokinetics of CJC-1295 DAC, potentially prolonging its half-life to around eight days.

Specifications

Other Known Titles: CJC-1295 with DAC

Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂

Molecular Weight: 3367.954 g/mol

Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Mal)-NH2

CJC-1295 DAC Research

CJC-1295 DAC and Pituitary Cell Receptors
Studies indicate that the peptide may enhance peak growth hormone levels up to seven and a half times in the models examined.^[3] CJC-1295 DAC may interact with specific binding sites on the growth hormone-releasing hormone (GHRH) receptor. Such interactions might alter the receptor’s configuration, potentially initiating a cascade of molecular events. This binding is thought to activate particular intracellular signaling proteins, commonly known as G-proteins.^[4] When these proteins are activated, they may facilitate the production of secondary messengers like cyclic adenosine monophosphate (cAMP) or inositol trisphosphate (IP3), which are considered to play essential roles in cellular signaling pathways.^[5] These secondary messengers are believed to activate protein kinases, enzymes that alter specific proteins. These kinases may modify cellular functions by phosphorylating transcription regulators, which are proteins that control gene expression. Upon phosphorylation, these transcription regulators are hypothesized to enter the nucleus of somatotroph cells, potentially affecting the genes that govern growth hormone production. This sequence of events underscores the potential of CJC-1295 DAC to influence growth hormone levels through a detailed network of molecular interactions.

CJC-1295 DAC and Growth Hormone Release
The peptide was initially developed to trigger growth hormone release and is a synthetic analog of the naturally occurring GHRH. Murine model experiments have reported that a single exposure to the peptide may induce almost 2-10 times higher production of growth hormone as compared to control models.^[6] GH expression appears to reach a maximum level after 2 hours of peptide introduction, and the action appears to be maintained up to six days later. The peptide appears to maintain the natural physiological level of growth hormone, unlike other secretagogues. In other words, CJC-1295 DAC may have the potential to perform as a physiological GHRH and maintain the natural biological high and low expression pattern in growth hormone levels. CJC-1295 DAC appears to maintain the physiological level of the hormone while enhancing its release in the blood. CJC-1295 DAC has been studied in relation to the physiological regulation of growth hormone in the course of protein synthesis, fat metabolism, blood sugar, hypertrophy, bone density, hyperplasia, and myocardial function. The production of growth hormone may interact with receptors on liver cells, potentially initiating a series of intracellular signaling events. This interaction may activate the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. Following activation, STAT proteins may possibly translocate to the nucleus and bind to specific DNA sequences known as response elements, which might facilitate the transcription of the IGF-I gene. It has been posited that CJC-1295 DAC may lead to increases in average IGF-I levels, ranging from 1.5- to 3-fold over approximately 9–11 days, with indications that these elevated levels might persist for at least two weeks in experimental settings. After repeated exposure to CJC-1295 DAC, average IGF-I levels seem to sustain an elevation above the initial baseline for up to 28 days. Importantly, data suggests a cumulative action with repeated exposures to the compound.^[6]